7/25/2023 0 Comments Taurine deficiency![]() ![]() On the other hand, increased levels of reactive oxygen species (ROS) and pro-inflammatory agents in target tissues are the most important determinants in patients susceptible to developing insulin resistance. Chronic hyperglycemia, along with insulin resistance following T2DM, is associated with increased oxidative stress and inflammation in various organs, which can lead to macrovascular and microvascular complications. However, the exact mechanisms underlying diabetes dyslipidemia are not completely understood, although visceral obesity, and subsequent insulin resistance partially explain impaired lipid metabolism. ![]() In particular, diabetic dyslipidemia, which is characterized by decreased levels of high-density lipoprotein (HDL-C), increased levels of very low-density lipoprotein (VLDL), total cholesterol, and synthesis of atherogenic low-density lipoprotein (LDL) particles, is associated with atherosclerotic lesions. Comorbid conditions, including hypertension and dyslipidemia, increase DM complications and thereby add to its overall morbidity and mortality. In particular, longer diabetes duration increases the risk of DM complications in diabetic patients diagnosed at a younger age. ![]() Type 2 diabetes mellitus (T2DM), as the most prevalent endocrine disease in the world, is characterized by chronic hyperglycemia, impaired pancreatic beta cell function, and insulin resistance in the target organs. Trial registration The protocol of this clinical trial is registered with the Iranian Registry of Clinical Trials (, identifier: IRCT20121028011288N16). The findings of this study showed that taurine supplementation improved some oxidative stress indices and inflammatory biomarkers in patients with T2DM. There were no differences in the serum levels of IL-6 or TAC. Also, a significant increase was observed in SOD ( p = 0.007), and CAT ( p = 0.001) in the taurine group compared with the placebo group. Following treatment, the taurine group had fewer serum levels of MDA ( p = 0.04), hs-CRP ( p = 0.002) and TNF-α ( p = 0.006) than the placebo group. There was a significant increase in SOD (5.1%, p = 0.004) and CAT (4.22%, p = 0.001) after 8 weeks of taurine supplementation. Anthropometric data, dietary intake, serum total antioxidant capacity (TAC), malondialdehyde (MDA), the activities of antioxidant enzymes superoxide dismutase (SOD) and catalase (CAT), serum levels of tumor necrosis factor alpha (TNF-α), interleukin 6 (IL-6) and high-sensitivity C-reactive protein (hs-CRP) were assessed before and after intervention. Methodsįifty patients with T2DM were randomly allocated to two groups to consume either taurine (containing 1000 mg taurine), or placebo (containing crystalline microcellulose) three times per day for 8 weeks. ![]() Hence, this study evaluated the effect of taurine supplementation on oxidative stress and inflammatory biomarkers in patients with T2DM. Dietary supplementation with taurine may attenuate oxidative stress and inflammatory responses in T2DM as well as alleviate diabetes-induced complications. Reduced serum level of taurine in type 2 diabetes mellitus (T2DM) was shown to be associated with the metabolic alterations and clinical complications of diabetes. ![]()
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